Journal of Interdisciplinary Medicine

A journal of basic and clinical medical research


The Journal of Interdisciplinary Medicine (JIM) has been created by a group of European researchers and healthcare specialists, in an attempt to provide the opportunity to share the current expertise and scientific achievements between the members of a large family of researchers and medical practitioners.

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Current Issue

Volume 2 // Issue 2 // June 2017

CardioIMAGE — the Image of a Cardio Team

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Magnetic Resonance Imaging of Myocardial Function Following Intracoronary and Intramyocardial Stem Cell Injection

ABSTRACT Stem cell-based therapy is a new therapeutic option that can be used in patients with cardiac diseases caused by myocardial injury. Cardiac magnetic resonance imaging (MRI) is a new noninvasive imaging method with an increasingly widespread indication. The aim of this re-view was to evaluate the role of cardiac MRI in patients with myocardial Read More ...

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Medication-Related Osteonecrosis of the Jaw: a Brief Review, Treatment and Practical Guidelines for Dentists

ABSTRACT Osteonecrosis of the jaws is a complication after treatment with antiresorptive drugs. Bisphos- phonates (BPs) are widely used to treat conditions with bone metastases of malignant tumors such as multiple myeloma, breast cancer, prostatic cancer, as well as hypercalcemia of ma-lignancy, osteoporosis, Paget’s disease, and osteogenesis imperfecta. Denosumab is an an-tiresorptive agent that is Read More ...

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Effects of Viral and Bacterial Infections on Marginal Periodontium

ABSTRACT Background: There are several risk factors, general and local, which favor the onset of peri-odontal destruction, and their knowledge is essential to their correct identification and for the adoption of a suitable therapeutic management. The aim of the study was to assess periodon-tal health status of patients suffering from viral and bacterial infections and Read More ...

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The Sensitivity and Specificity of Fine- Needle Aspiration in Thyroid Neoplasia

ABSTRACT Objective: To evaluate and demonstrate the accuracy of fine-needle aspiration (FNA) in thy-roid lesions in our department and to highlight probable causes of errors leading to unsatis-factory sampling, which may depend on the characteristics of the nodule. Methods: This is a retrospective study conducted on 319 diagnosed cases of thyroid nodules referred to the Read More ...

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Time-Dependent Drug Administration in Hypertension and its Effect on Blood Pressure Variability

ABSTRACT Background: Optimizing blood pressure variability seems to represent a new therapeutic target in the management of hypertension. It is emphasized that scheduling at least one an-tihypertensive agent at bedtime, has the ability to reduce blood pressure. Aim of the study: We have proposed to test whether the divided treatment regimen also lowers blood pres-sure Read More ...

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Computed Tomographic Assessment of Coronary Arteries in Patients Undergoing Stem Cell Therapy Following an Acute Myocardial Infarction

ABSTRACT Despite of numerous treatment strategies developed in the last years, ischemic heart disease remains the leading cause of death around the world. Acute myocardial infarction (MI) causes irreversible destruction to the myocardial tissue, which is replaced by fibroblast cells, lead-ing to the formation of a dense, collagenous scar, a non-contractile tissue, and often to heart failure. Stem Read More ...

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Cardiac Computed Tomography Assessment in Acute Coronary Syndromes — Do We Have Time for It in Emergency Settings?

ABSTRACT The diagnosis and treatment of acute coronary syndrome remain a challenge for clinicians in many clinical settings, especially in patients with previous low-to-intermediate risk. Due to its high specificity and sensitivity for detecting significant coronary artery stenoses, cardiac com-puted tomography angiography (CCTA) tends to be used more frequently in the emergency room (ER) in the last years. Read More ...

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New Treatment Methods in Multiple Myeloma

ABSTRACT Multiple myeloma accounts for 10% of the hematologic malignancies and is characterized by a single clone of plasma cells producing a monoclonal protein. The aim of this review is to sum-marize the current treatment methods of multiple myeloma. In the last 15 years, the incidence of myeloma has increased in patients younger than 65 years, thus Read More ...

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High-Risk Coronary Plaques Complicated with Acute Coronary Syndrome in Young Patients

ABSTRACT Coronary computed tomography angiography (CCTA) has evolved notably over the last de-cade, gaining an increased amount of temporo-spatial resolution in combination with de-creased radiation exposure. The importance of CCTA is emerging especially in vulnerable and young patients who might not have developed a viable collateral vascular network to sustain the circulation to an infarction area during Read More ...

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Computed Tomography Assessment of Coronary Fistulas

ABSTRACT Coronary artery fistulas, a rare anomaly, are represented by an abnormal communication be-tween the coronary arteries and other vascular structures or cardiac chambers and, in most cases, are detected incidentally. Regularly, they do not cause important pathological changes, but if the symptoms persist, they need to be treated. The hemodynamic impact depends on the localization and size Read More ...

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Unrelated Allogeneic Stem Cell Transplantation in a Patient with Chronic Myeloid Leukemia in Blast Crisis

ABSTRACT Chronic myeloid leukemia (CML) is a clonal myeloproliferative disorder, which can involve the hematopoietic stem cell or early progenitor cells, without the loss of their capacity to differenti-ate. Typically, CML has three clinical phases: a chronic phase, an accelerated phase, and an aggressive transformation in blast crisis, analogous to acute leukemia. The following article presents Read More ...

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Severity Stratification by Compression Ultrasound Examination in Lipodermatosclerosis and Diabetic Dermopathy Patients: a Report of Three Cases

ABSTRACT Lipodermatosclerosis and diabetic dermopathy are low-risk skin lesions with many similar clinical features, except for venous abnormalities such as chronic venous insufficiency, but are rarely a reason for referring the patient to vascular ultrasound examination. We present 3 serial cases in which the compression ultrasound examination (CUS) of the venous circulation of the affected limbs was of utmost Read More ...

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Knuckle Pads – Practical Diagnostic Issues

ABSTRACT Knuckle pads are thickening of the skin over the extensor surface of the proximal interphalan- geal joints. Clinical picture, ultrasound imaging, and histopathological examination of the skin biopsy ascertain the diagnosis. In routine practice, two main differential diagnoses are important: knuckle pads vs. pseudo-knuckle pads and idiopathic vs. non-idiopathic forms of knuckle pads.

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Screening for Cognitive Dysfunction Helped to Unmask Silent Cerebrovascular Disease in a Hypertensive Diabetic Patient — Case Report

ABSTRACT The current guidelines for the diagnosis and treatment of hypertension recommend screening for cognitive impairment in all hypertensive patients as part of the clinical assessment. How-ever, the implementation of this recommendation in clinical practice is still unsatisfactory. We present the case of an elderly hypertensive female patient in order to highlight the importance of screening Read More ...

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Published Online Ahead of Print

Online Articles

Myocardial Infarction Complicated with Ventricular Rupture and Pseudo-Aneurysm Formation

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Computer-Aided Diagnosis in Colorectal Cancer: Current Concepts and Future Prospects

ABSTRACT Colorectal cancer is an important health issue, both in terms of the number of people affected and the associated costs. Colonoscopy is an important screening method that has a positive impact on the survival of patients with colorectal cancer. The association of colonoscopy with computer-aided diagnostic tools is currently under researchers’ focus, as various Read More ...

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Correlations between Chronological Ages and Dental Ages on a Group of Children with Down Syndrome

ABSTRACT Background: The number of studies on oral complications in children with Down syndrome is substantial, but they are focused rather on the prevalence of dental caries, periodontal disease, and hypodontia. The relationship between Down syndrome and dental eruption has been rarely approached. The causes of delayed eruption in children with Down syn- drome are Read More ...

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Comparative Measurements of Aortic Diameters Using Transthoracic Echocardiography and Thoracic Computed Tomography Angiography in Neonatal Aortic Coarctation

ABSTRACT Background: Critical aortic coarctation is defined as the severe narrowing of the isthmic aortic lumen, representing a neonatal cardiac emergency, part of the congenital heart diseases with duct-dependent systemic circulation. Aim of the study: To assess the correlation between transthoracic echocardiography and computed tomography angiography (CTA) in the mea- surement of aortic diameters in Read More ...

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Supralevator Total Pelvic Exenteration Without Colostomy — Case Report

ABSTRACT Background: Pelvic exenteration is an ultra-radical surgical procedure described by Brunschwig in 1948, which attempts to surgically cure patients with recurrent pelvic cancer after radiotherapy. Several variants of pelvic exenteration are described that allow a more limited or extensive resection, depending on the stage of the disease. Case report: We report the case of a 54-year-old woman, who Read More ...

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Multiple Coronary Chamber Microfistulas or Persistent Thebesian Vessels?

ABSTRACT Coronary fistulas are rare, not gender-specific congenital conditions, consisting of communications between the coronary arteries and either another coronary vessel or a cardiac chamber. In contrast to large fistulas, small fistulas, named “minimae cordis veneae” or the Thebesius venous system, are draining into heart chambers and form a vascular network in the cardiac lumen. In this article, we Read More ...

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Actual Dose-Reduction Strategies in Cardiac Computed Tomography

ABSTRACT Computed tomography (CT) in cardiac examination is a powerful imaging tool that has developed rapidly during the last decade and continues to increase its potential by bringing novel technologies. Due to its noninvasive character, cardiac CT became a largely used method in detecting coronary diseases or functional issues at the expense of conventional coronary angiography. The accuracy of Read More ...

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Cardiac Magnetic Resonance and Myocardial Viability: Why Is It so Important?

ABSTRACT For a better assessment of ischemic heart diseases, myocardial viability should be quantified. Current studies underline the importance and the evolution of several techniques and methods used in the evaluation of myocardial viability. Taking into account these considerations, the aim of this manuscript was to present the recent points of view regarding myocardial viability and its clinical significance Read More ...

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Spontaneous Coronary Artery Dissection as a Cause of Acute Coronary Syndrome in a Young Male Patient with Multiple Cardiovascular Comorbidities

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Intraoperative Differential Diagnosis: Double Gallbladder or Serous Cyst in the Gallbladder Bed?

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Magnetic Resonance Imaging in Myocardial Fibrosis Related to Ischemic Events

ABSTRACT Given the higher amount of detail it offers, the use of magnetic resonance (MR) in the field of cardiology has increased, thus leading to a decrease in the use of invasive and irradiating methods for diagnosing various cardiovascular disorders. The only precautions for MR imaging are metallic implants and advanced-stage chronic kidney disease. For Read More ...

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The Whitening Efficiency on Colored Teeth

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The Role of Coronary Computed Tomography Angiography and Cardiac Magnetic Resonance in STEMI Patients with Normal Coronary Angiography

ABSTRACT Usually, the diagnosis of myocardial infarction based on patient symptoms, electrocardiogram (ECG) changes, and cardiac enzymes, is not a challenge for cardiologists. The correlation between coronary anatomy and the ECG territories that present ischemic changes can help the clinician to estimate which coronary artery presents lesions upon performing a coronary angiogram. In certain situations, Read More ...

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Acute Thrombotic Coronary Occlusion in a Patient with Coronary Artery Anomaly

ABSTRACT Patients with coronary artery anomalies are more susceptible to develop acute thrombotic coronary occlusions due to the abnormal anatomy of these arteries and the disturbance of the pathophysiological mechanisms that lead to an accelerated atherosclerosis development. The following article presents the case of a 64-year-old female patient diagnosed with anterior ST-segment elevation myocardial infarction. Read More ...

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Management of Microvascular Complications in Secondary Diabetes Associated with Autoimmune Diseases — Case Report

ABSTRACT The association of multiple autoimmune diseases may represent the main focus of physicians treating patients with such pathology presenting no comorbidities of different etiology. However, autoimmune diseases and side effects of drugs may lead to development of silent health-threatening diseases that should be identified promptly. We present the case of an elderly, obese, Caucasian female patient suffering of Read More ...

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Leukemia with Plasma Cells — Case Report

ABSTRACT Plasma cell leukemia (PCL) is one of the most aggressive monoclonal gammopathies, being characterized by the presence of more than 20% of plasma cells in the peripheral blood and an absolute number of these cells of more than 2×109, with different morphology, from young elements to mature cells. The incidence of PCL varies between Read More ...

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Preliminary Assessment of Risk Factors for Tooth Wear

ABSTRACT Background: Epidemiological studies have reported an increasing prevalence of tooth wear, and general dental practitioners see a greater number of patients seeking treatment with worn dentition. Improper oral hygiene, unhealthy habits, occupational hazards, and potentially erosive processed foods seem to play a major role in the non-carious loss of dental hard tissue. The aim Read More ...

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Use of Circulating and Cellular miRNAs Expression in Forensic Sciences

ABSTRACT The current practice in the field of forensic medicine imposes the use of modern investigation techniques. The complexity of laboratory investigation methods needed for a final result of the investigation in forensic medicine needed new biomarkers of higher specificity and selectivity. Such biomarkers are the microRNAs (miRNAs), short, non-coding RNAs composed of 19–24 nucleotides. Their characteristics, such as Read More ...

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Simultaneous Determination of Carbamazepine and Carbamazepine- 10,11-epoxide in Different Biological Matrices by LC-MS/MS

ABSTRACT An uncomplicated, sensitive liquid chromatography linked to mass spectrometry (LC/MS) for evaluation of carbamazepine and carbamazepine-10,11-epoxide (its metabolite) in human plasma, human saliva, rat plasma, and rabbit plasma was developed. Analyses were conducted on a Zorbax SB-C18, 100 mm × 3 mm ID, 3.5 μm column, at a column temperature of 40 ºC. The Read More ...

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The Detection of Proximal Colon Polyps and Its Importance in Screening Colonoscopy

ABSTRACT Background: Colon polyps are precursors of colorectal cancer (CRC), therefore their endoscopic detection is very important. A shift of in the localization of colorectal polyps toward the proximal colon has been recently observed in Western countries. Aim: The aim of this paper was to establish the most important clinical and endoscopic aspects of right Read More ...

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Prevention of Primary ACL Injuries: A Novel, Innovative Approach

ABSTRACT Anterior cruciate ligament (ACL) injuries are increasing amongst professional and recreational athletes, and creating prevention programs to reduce the occurrence of ACL damages is becoming a necessity. To prevent an ACL tear, it is necessary to comprehend the mechanisms and the risk factors of injury. Biomechanical and clinical studies try to understand these complex Read More ...

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Will Total Knee Replacement Ever Provide Normal Knee Function?

ABSTRACT Knee osteoarthritis or gonarthrosis is considered the most common joint disease, affecting more than 70% of subjects aged over 65 years. Its occurrence is increasing with age and is more problematic with the current rise in the incidence of obesity. In severe and advanced cases, total knee arthroplasty is recommended as a gold standard Read More ...

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Anatomic All-Inside Anterior Cruciate Ligament Reconstruction Using the TransLateral Technique

ABSTRACT Background: Anterior cruciate ligament (ACL) reconstruction is a commonly performed procedure and considered to be the gold standard in restoring knee function and stability in ACL-deficient knees. The TransLateral all-inside technique implies the use of only two portals – anterolateral and anteromedial, without the use of an accessory portal. The work is done using Read More ...

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Intracoronary Shear Stress and CT Characteristics of Vulnerable Coronary Plaques

ABSTRACT Vulnerable coronary plaques are associated with a significant risk for rupture, and the ability to detect their characteristic features is of extreme importance, as timely detection of rupture-prone plaques could lead to the appropriate initiation of adequate therapeutic measures and prevent the evolution to an acute coronary event. The most common features of vulnerability in coronary plaques are Read More ...

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